Pre-emptive analgesia–why the evidence is conflicting

Effectiveness of pre-emptive analgesia is unproven

Study Selection Studies were selected if they were randomised controlled trials (RCTs) that compared the outcome when analgesics were given before surgical incision with the outcome when the same medication was given after surgical incision. Studies that compared pre-emptive analgesia with no analgesia or that compared pre-emptive analgesia with pre-emptive analgesia plus analgesia given after ...

Effectiveness of pre-emptive analgesia is unproven

Study Selection Studies were selected if they were randomised controlled trials (RCTs) that compared the outcome when analgesics were given before surgical incision with the outcome when the same medication was given after surgical incision. Studies that compared pre-emptive analgesia with no analgesia or that compared pre-emptive analgesia with pre-emptive analgesia plus analgesia given after ...

Shareholders’ Pre-Emptive Rights

What is the role of NSAIDs in pre-emptive analgesia?

NSAIDs inhibit the cyclo-oxygenase enzymes, and decrease peripheral and central prostaglandin production. In addition to reducing the inflammation that accompanies tissue injury, decreasing prostaglandin production attenuates the response of the peripheral and central components of the nervous system to noxious stimuli. Such a reduction in the response to pain can reduce the peripheral and cent...

Pre-emptive analgesia.

Transmission of pain signals evoked by tissue damage leads to sensitization of the peripheral and central pain pathways. Pre-emptive analgesia is a treatment that is initiated before the surgical procedure in order to reduce this sensitization. Owing to this 'protective' effect on the nociceptive system, pre-emptive analgesia has the potential to be more effective than a similar analgesic treat...